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剖析上升大动脉动脉瘤 (斯坦福A型剖析) 的特定层生物机械特性

Marta Kozuń¹, Maciej Kaczorowski², Agnieszka Hałoń²

¹Department of Mechanics, Materials and Biomedical Engineering, Wrocław University of Science and Technology, Wrocław, Poland.

Acta of bioengineering and biomechanics

|February 5, 2024

概括

冒险器为上升性大动脉动脉瘤提供了至关重要的机械保护,即使在切割的组织中也保持其功能. 其他层,如介质和内膜,也有助于动脉瘤壁中的负载转移.

科学领域:

生物医学工程生物医学工程
心血管研究研究心血管研究
材料科学材料科学材料科学

背景情况:

上升性大动脉动脉瘤是一种危及生命的疾病,其特点是大动脉壁衰弱.
了解动脉瘤壁的机械特性对于预测破裂风险至关重要.

研究的目的:

分析剖析的上升大动脉动脉瘤壁的机械特性.
为了比较不同大动脉壁层的机械贡献.

主要方法:

对切割的上升大动脉动脉瘤壁进行了方向拉力测试 (n=12).
使用血素和素,马洛里三色素和阿赞染料的组织学分析补充了生物力学试验.

主要成果:

冒险体表现出最高的机械强度,故障的中位数为考奇应力,故障力,模和刚度系数.
失败Cauchy压力在介质和内心是可比的 (分别为0.23MPa和0.21MPa).

结论:

在健康和剖析的上升大动脉动脉瘤组织中, adventitia 保护血管的机械功能保持一致.
大动脉剖析改变了上升的大动脉壁层的机械性质.
剖开的动脉瘤壁中的机械负荷可能会通过介质和内膜传递.

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