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19 作为抗菌菌剂的希夫基:合成,分子对接和可信的作用机制

Yu-Xiang Cai1, Jun-Xian Chen1, Hong-Mei Dong1

  • 1College of Pharmacy, Guizhou University, Guiyang, 550025, China.

Future medicinal chemistry
|February 5, 2024
PubMed
概括

研究人员合成了19种化合物,以寻找针对Mycobacterium tuberculosis (Mtb) 的新药. 化合物19显示最有前途,作为一种具有新奇机制的潜在抗Mtb.

关键词:
结核病菌菌菌的结核病菌的结核病菌.希夫基混合动力混合动力综合合成是一种合成.

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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