德克萨斯州门缩和狭窄的流行情况和描述性流行病学,1999-2018年
Renata H Benjamin1, Lisa K Marengo2, Angela E Scheuerle3
1Department of Epidemiology, UTHealth School of Public Health, Houston, Texas, USA.
American journal of medical genetics. Part A
|February 5, 2024
概括
这项研究揭示了门缩/缩的患病率,这是先天性鼻阻塞的常见原因. 发现了与婴儿和母亲特征的关联,特别是单独的双边门缩/狭窄.
科学领域:
- 儿科耳鼻喉科 儿科耳鼻喉科
- 出生缺陷流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 门缩/狭窄是先天性鼻阻塞的常见原因,但其流行病学仍然不清楚.
- 与双边病例相比,单边门缩症/狭窄症往往是晚些时候诊断出来的,并且在注册表中可能报告不足.
- 了解门缩/门缩的患病率和风险因素对于早期诊断和干预至关重要.
研究的目的:
- 为了确定德克萨斯州门缩/缩的患病率.
- 为了确定与门缩/缩相关的婴儿和母亲的特征.
- 为了比较单独的门缩/缩和单独的双边门缩/缩之间的流行病学发现.
主要方法:
- 利用了德克萨斯州出生缺陷登记和生命记录 (1999-2018) 的数据.
- 采用波桑回归模型来分析与婴儿和母亲因素的关联.
- 对两个组进行了分析:孤立的门缩/狭窄和孤立的双边门缩/狭窄.
主要成果:
- 门缩症的总体患病率为每10,000例活产中的0.92.
- 隔离的门缩/狭窄的患病率为每1万活产儿0.37.
- 相关因素包括婴儿的性别,多重怀孕,母亲的种族/种族,母亲的年龄,以及母亲在德克萨斯 - 墨西哥边境附近的居住地.
结论:
- 关于孤立的门缩/缩的流行病学研究可能会从专注于双边病例中获益.
- 进一步的研究应该调查与母亲在德克萨斯 - 墨西哥边境居住有关的环境,社会和结构因素.
- 这些发现突显出需要改善对门缩/缩的确诊和有针对性的研究.
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