对具有广泛宿主范围的Alphabaculovirus病毒与宿主共同进化的分析
Xiaoqin Yang1,2, Xiaowei Peng1, Chengfeng Lei1
1Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China.
The Journal of general virology
|February 5, 2024
概括
从昆虫幼虫中发现了两种新的alphabaculovirus分离物. 遗传学分析表明它们属于Alphabaculovirus mabrassicae物种,Mamestra brassicae作为祖先宿主.
科学领域:
- 病毒学 病毒学
- 昆虫学 昆虫学是一门学科.
- 遗传学 是一个遗传学.
背景情况:
- 细菌病毒通常表现出高宿主特异性,只感染一种或少数密切相关的昆虫物种.
- 存在例外情况,例如Alphabaculovirus aucalifonicae和Alphabaculovirus mabrassicae,它们具有更广泛的宿主范围.
研究的目的:
- 为了识别和表征来自Mamestra brassicae和Mythimna separata幼虫的新型alphabaculovirus分离物.
- 确定这些分离物与已知的baculoviruses及其宿主之间的遗传关系.
- 研究baculoviruses及其昆虫宿主共同进化的历史.
主要方法:
- 隔离和命名两个新的alphabaculovirus分离物:Mamestra brassicae多重核多重体病毒分离物QD (MbMNPV-QD) 和Mythimna separata多重核多重体病毒分离物Hb (MyseMNPV-Hb).
- 基穆拉对38个连接的核心baculovirus基因进行了双参数分析,以评估遗传距离.
- 用20个病毒同源基因序列和13个昆虫宿主的线粒体蛋白质编码基因来构建家族遗传树.
主要成果:
- 从它们各自的宿主幼虫中确定了MbMNPV-QD和MyseMNPV-Hb.
- 遗传分析显示,MbMNPV,MyseMNPV-Hb,HearMNPV和MacoNPV-B都是同一种病毒物种的分离物.
- 遗传学分析表明,Mamestra brassicae是这些病毒分离物的祖先宿主.
结论:
- 新发现的分离物,以及HearMNPV和MacoNPV-B,代表了现有的病毒物种Alphabaculovirus mabrassicae的独特分离物.
- Mamestra brassicae被确定为这个群体中最可能的祖先宿主,这表明了共进化的关系.
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