在患有癌症的患者中,不经常过渡到直接口服抗凝剂
Nina Nouhravesh1, Caroline Sindet-Pedersen1, Maja Hellfritzsch2
1Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte Hospital.
Danish medical journal
|February 5, 2024
概括
由于药物相互作用,直接口服抗凝剂 (DOAC) 在癌症患者中存在挑战. 这项研究发现,不到35%的符合条件的癌症患者在一年内从低分子量肝素转换为DOAC,这表明可以改善抗凝治疗的空间.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 药理学药物相互作用 (DDI) 在癌症患者中复杂化了直接口服抗凝剂 (DOAC) 的使用.
- 评估DOAC和抗瘤剂之间的潜在DDI对于安全有效的治疗至关重要.
研究的目的:
- 评估DOAC和抗瘤剂之间潜在的DDI的流行情况.
- 确定癌症患者从低分子量肝素 (LMWH) 转换为DOAC的一年累积发病率.
主要方法:
- 分析了2014-2019年接受LMWH的161名癌症患者的队列.
- 阿伦-约翰森估计器计算了转换到DOACs的一年发生率.
- 使用欧洲心律协会 (EHRA) 的指导方针和Hellfritzsch等使用潜在的DDI被确定. 审查. 审查.
主要成果:
- 在符合条件的癌症患者中,从LMWH切换到DOAC的一年累计发病率为32%.
- 使用EHRA标准,24%的抗瘤剂具有潜在的DDI;这下降到8%的Hellfritzsch等. 数据. 数据. 数据.
- 该研究确定了大量的DOAC和抗瘤剂之间的潜在DDI.
结论:
- 在符合条件的癌症患者中,一年内从LMWH转换到DOAC的转换率低于35%,这表明有机会优化抗凝剂管理.
- 在临床实践中,对DOAC和抗瘤剂之间潜在的DDI的当代数据至关重要.
- 需要改进的策略,以安全地将DOAC纳入癌症患者护理,考虑到潜在的药物相互作用.
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