在MASLD中的"多米诺效应":脂肪肝炎的炎症级联
Karlo Mladenić1, Maja Lenartić1, Sonja Marinović1,2
1Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
European journal of immunology
|February 5, 2024
概括
代谢功能障碍相关的脂肪性肝病 (MASLD) 通过三阶段的炎症过程发展为代谢相关的脂肪性肝炎 (MASH). 了解这种级联为肝脏疾病提供了新的治疗点.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球超过25%的成年人.
- 进展到代谢相关的脂肪肝炎 (MASH) 显著增加肝硬化和肝癌的风险.
- MASH的发病过程涉及肝脏内的复杂,多因素的炎症过程.
研究的目的:
- 为了阐明连续的炎症阶段驱动MASH病理生理学.
- 突出炎症作为潜在的生物标志物和MASLD的治疗目标.
主要方法:
- 对MASH炎症途径的当前证据的审查和综合.
- 在MASH中描述肝炎的三阶段模型.
- 讨论免疫细胞参与和关键介质分泌.
主要成果:
- 第1阶段:由常驻免疫细胞 (如 γδ T 细胞) 检测到的肝细胞应激,释放IL-17A.
- 第二阶段:通过TNF,TGF-β和IL-1β招募髓状细胞并启动炎症.
- 第三阶段:淋巴细胞透 (Th17,CD8 T,B细胞),导致慢性炎症,星状细胞激活和纤维化.
结论:
- MASH进展的特点是多米诺状的炎症事件级联.
- 针对特定的炎症媒介和细胞为MASLD提供了一个有希望的治疗途径.
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