在2型生物使用后的现实世界不良事件 慢性鼻炎与鼻多
Marisa Dorling1, Juan C Hernaiz-Leonardo2, Athenea Pascual2
1Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
The Laryngoscope
|February 5, 2024
概括
杜皮卢马布和梅波利祖马布在患有鼻息肉的慢性鼻炎患者中显示出不同的不良事件概况. 这些真实数据有助于为2型生物治疗做出临床决策.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 带鼻息肉的慢性鼻炎 (CRSwNP) 是一种复杂的炎症状况.
- 2型生物药物,如dupilumab和mepolizumab越来越多地用于CRSwNP的管理.
- 了解他们的现实世界不良事件概况对于患者安全至关重要.
研究的目的:
- 确定CRSwNP患者中与dupilumab和mepolizumab相关的不良事件的频率和类型.
- 在现实环境中比较这两种生物制剂的安全性.
- 识别不良事件的潜在风险因素.
主要方法:
- 从单一机构获得的真实世界数据的回顾性分析.
- 纳入标准:CRSwNP诊断,先前的内镜外科手术,以及至少两剂杜皮卢马布或梅波利祖马布.
- 主要结果:不良事件的发生率和性质;用于比较和风险因素分析的后勤回归.
主要成果:
- 45%的dupilumab患者 (n=87) 和20%的mepolizumab患者 (n=51) 经历了不良事件.
- 杜皮卢马布的常见不良事件包括关节痛,皮疹和结膜炎; 梅波利祖马布包括头痛和疲劳.
- 相比于mepolizumab,dupilumab在不良事件 (3.8) 中的概率比率显著更高.
结论:
- 杜皮卢马布和梅波利祖马布在CRSwNP患者中表现出不同的不良事件概况.
- 现实世界的数据表明,与dupilumab相比,dupilumab的不良事件发生率高于mepolizumab.
- 结果支持对CRSwNP的2型生物选择做出明智的临床决策.
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