在Achromobacter属中, siderophore 生产的流行程度和变异性
P Sorlin1, E Brivet1, V Jean-Pierre1,2
1HydroSciences Montpellier, Université de Montpellier, CNRS, IRD, Montpellier, France.
Microbiology spectrum
|February 5, 2024
概括
经常在囊性纤维化患者中发现的Achromobacter细菌通常产生 siderophores,这对生长至关重要. 临床菌株,特别是Achromobacter xylosoxidans,表现出更高的 siderophore 产量,这可能解释了它们在人类感染中的成功.
科学领域:
- 微生物学 微生物学
- 病原体研究 病原体研究
- 细菌的毒性因素 细菌的毒性因素
背景情况:
- 亚克罗巴克特菌 spp. 的种类. 是机会性病原体,越来越多地从囊性纤维化 (CF) 和其他疾病患者中分离出来.
- 阿克罗巴克特菌种类的毒性因子. 不是完全了解,与 siderophore 生产之前未经调查在这个属.
- 赛多对细菌生长和营养获取至关重要.
研究的目的:
- 为了评估大量的Achromobacter spp.集中的 siderophore 产量.
- 根据菌株来源 (临床与环境) 和物种,评估 siderophore 生产的变异性.
- 研究 siderophores 在 Achromobacter 感染病理生理学和流行病学成功中的潜在作用.
主要方法:
- 总共分析了163种Achromobacter菌株 (128种临床,35种环境).
- 使用青醇-硫酸盐试验进行了 siderophore 量化.
- 通过nrdA基因基因基因鉴定实现了物种鉴定.
主要成果:
- 在72.4%的阿克罗姆巴克特菌株中检测到 siderophore 生产.
- 与环境菌株相比,临床菌株的流行率和 siderophores 的产量明显更高.
- 亚克罗巴克特 (Achromobacter xylosoxidans) 显示出 siderophore 生产的高患病率,特别是在CF患者的菌株中.
结论:
- 侧虫的生长是阿克罗巴克特菌属的一个共同特征,在临床分离物中尤其普遍.
- 种类和起源之间 siderophore 生产的差异表明它们在 Achromobacter 病原发生中的重要性.
- 丝虫可能有助于Achromobacter xylosoxidans在人类感染中的流行病学成功.
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