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前列腺素E-主要的尿路代谢物作为急性介质缺血的新生物标志物
Keisuke Suzuki1, Koji Morishita, Tomohiro Adachi
1From the Department of Acute Critical Care and Disaster Medicine, Graduate School of Medical and Dental Sciences (K.S., K.M., T.A.), Department of Acute Critical Care and Disaster Medicine (A.S., K.N.), Tokyo Medical and Dental University Hospital of Medicine, Tokyo; Department of Acute Critical Care Medicine (K.S.), Tsuchiura Kyodo General Hospital, Tsuchiura, Ibaraki; Emergency and Critical Care Center (M.K.), Tokyo Women's Medical University Medical Center East, Tokyo, Japan; Trauma Unit, Department of Surgery, Faculty of Medicine (P.T.), Khon Kaen University, Khon Kaen, Thailand; Comparative Effectiveness and Clinical Outcomes Research Center-CECORC (R.C.), Riverside University Health System Medical Center, Moreno Valley, California; and National Hospital Organization Disaster Medical Center (Y.O.), Tokyo, Japan.
泌尿前列腺素E2主要尿代谢物 (PGE-MUM) 的水平随着大鼠的肠道缺血-再输血而增加. 这表明PGE-MUM可能作为检测肠道缺血症的非侵入性生物标志物.
科学领域:
- 血管外科 血管外科
- 胃肠病学 胃肠病学
- 生物标志物发现发现
背景情况:
- 急性中肠缺血 (AMI) 是影响小肠的关键血管紧急情况.
- 尽管有进展,但AMI的死亡率很高.
- 前列腺素E2主要尿路代谢物 (PGE-MUM) 是肠道炎症的稳定尿路生物标志物.
研究的目的:
- 调查尿PGE-MUM水平是否与肠道缺血症的严重程度相关.
- 评估PGE-MUM作为肠道缺血-再输液损伤的潜在非侵入性生物标志物.
主要方法:
- 建立了一种鼠标模型,用于表层中枢动脉封闭 (SMAO).
- 老鼠经历了30或60分钟的缺血,随后进行了3或6小时的再输血.
- 测量了尿中的PGE-MUM水平,并将其正常化为尿中的肌.
主要成果:
- 与假装组相比,SMAO组的组织学损伤得分明显高于SMAO组.
- 在SMAO组中,尿液中的PGE-MUM水平和PGE-MUM/肌素比率显著升高.
- 较高的PGE-MUM水平与较长的缺血持续时间相关.
结论:
- 肠道缺血-再输液显著增加尿PGE-MUM水平以时间依赖的方式.
- PGE-MUM显示出作为评估肠道缺血症的非侵入性生物标志物的潜力.
- 需要进一步的研究来验证PGE-MUM在临床环境中的有效性.
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