人类骨病的临床前动物模型,包括对皮层骨的关注
Natalie Y Y Koh1,2, Justyna J Miszkiewicz3,4, Mary Louise Fac1,2
1Bone Cell Biology & Disease Unit, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.
Endocrine reviews
|February 5, 2024
概括
临床前模型对于了解骨质疏松症等骨疾病至关重要. 本研究回顾了它们的使用,重点关注皮质骨,并提供了指导方针,以便在骨研究中更好地报告和解释小鼠模型.
科学领域:
- 骨生物学和疾病
- 临床前研究模型 临床前研究模型
- 骨生理学 骨生理学
背景情况:
- 临床前模型,主要是老鼠和小鼠,是骨生物学研究的基础.
- 这些模型在开发治疗骨质疏松症和遗传骨疾病的疗法方面发挥了重要作用.
- 治疗骨疾病的进步,特别是皮质骨强度,需要对临床前模型进行更好的理解和报告.
研究的目的:
- 描述小鼠,老鼠和人类的骨结构发育,维护和退化.
- 在内分泌条件的临床前模型中检查皮质骨变化.
- 为在骨研究中一致使用和解释小鼠模型提供准则.
主要方法:
- 对小鼠,老鼠和人类的脑和皮层骨发育,维护和衰老的审查.
- 在内分泌疾病 (骨质疏松症,CKD,甲状腺功能增强症,糖尿病) 的临床前模型中分析皮层骨结构.
- 在将动物模型与人类骨进行比较时,讨论常见的担忧,重点关注皮层骨差异.
主要成果:
- 皮层骨结构在小型和大型哺乳动物之间有所不同.
- 控制皮层骨强度和结构的机制在小鼠和人类中都很常见.
- 最近的发现突出了在整个寿命阶段对皮质多孔性和骨细胞网络的遗传贡献者.
结论:
- 改善对临床前模型的理解和严格报告对于骨生物学中的治疗进展至关重要.
- 提供了指导方针,以提高鼠标模型的使用和解释的一致性.
- 在临床前研究中专注于皮质骨是非常重要的,因为它在不同的哺乳动物中具有独特的结构.
相关概念视频
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01:26Bone Markings
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Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...