住院肌素检测频率对急性损伤鉴定和分期的影响:一项历史队列研究
Catarina Luz Oliveira1,2, Filipa Duarte-Ramos1,3, Filipa Alves da Costa4
1iMED, Research Institute for Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
International journal of clinical pharmacy
|February 5, 2024
概括
血清肌素检测的医院实践往往错过了急性损伤 (AKI) 病例. 更频繁的测试对于准确的AKI识别和及时的药物剂量调整至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 临床药房 临床药房
- 医院 医院 医疗 医疗 医疗 医疗
背景情况:
- 急性损伤 (AKI) 是一种常见的,严重的疾病,通常是由药物引起的.
- 精确识别和分期AKI需要定期监测血清肌素 (SCr).
研究的目的:
- 评估现实世界的医院SCr测试实践如何影响AKI识别和分期.
- 评估测试频率对AKI患者药物剂量调整的影响.
主要方法:
- 一项历史的队列研究分析了成人患者的医院记录 (2018年06月01日~2020年12月31日).
- 使用AKIN和KDIGO标准诊断AKI,并考虑SCr测试间隔.
- 计算包括估计的淋巴膜过率 (eGFR) 和动态eGFR (KeGFR).
主要成果:
- 近一半的住院病例 (46.8%) 的SCr测试间隔超过48小时.
- 在7.0% (AKIN) 和9.1% (KDIGO) 的患者中发现了AKI.
- 忽视时间间隔表明AKI的低诊断率为37.5% (AKIN) 或19.1% (KDIGO),许多人接受剂量调整的药物.
结论:
- 目前的医院SCr测试协议不足以及时检测AKI.
- 增加Scr测试的频率是必要的,以改善患者的护理.
- 扩大临床药剂师的角色可以促进必要的实践变化.
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