二氧化污染与中国因特定原因死亡率之间的关联:跨截面时间序列研究
Jie Zeng1, Guozhen Lin2,3, Hang Dong2,3
1Department of Internet Medical Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
JMIR public health and surveillance
|February 5, 2024
概括
短期暴露于二氧化 (NO2) 增加了因各种原因,包括心血管和呼吸道疾病的死亡风险. 弱势群体可能面临更高的风险,强调需要更新NO2暴露指南.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 二氧化 (NO2) 与全球疾病和死亡率有关.
- 有限证据表明,在各种死亡原因中,NO2的风险有限.
- 之前的研究没有足够的混因素调整和有限的暴露评估分辨率.
研究的目的:
- 量化评估短期NO2暴露与中国广州各种死亡原因的联系.
- 为了调整NO2死亡关系中的潜在混因素.
- 为了确定性别和年龄是否会改变NO2对死亡率的影响.
主要方法:
- 一项时间序列研究分析了广州2010年至2018年的413,703例死亡.
- 使用准森回归的通用添加模型估计了NO2对因特定原因死亡率的滞后效应 (0-4天).
- 分层分析通过气象因素,性别和年龄来检查影响.
主要成果:
- 10μg/m3的NO2增加与所有原因 (1.73%) 的死亡风险增加相关,非意外原因 (1.75%),心血管疾病 (2.06%),呼吸系统疾病 (2.32%),内分泌疾病 (2.40%),瘤 (1.18%).
- 死亡风险与26个子类别中的16个相关,包括高血压疾病和缺血性中风.
- 在低温,湿度和风速下观察到更高的NO2效应,除了空气压力和内分泌疾病的一些例外.
结论:
- 短期的二氧化 (NO2) 暴露会增加因多种原因而导致的死亡风险.
- 易受伤害的人群可能面临更高的风险,因此需要更新中国的NO2暴露指南.
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