在纤维化间歇性肺部疾病中对呼吸障碍视觉模拟尺度的验证
Luka Bevanda1, Valerie Mok1, Kenny Lin1
1Department of Medicine and.
Annals of the American Thoracic Society
|February 5, 2024
概括
视觉模拟尺度 (VAS) 对于呼吸障碍被验证为纤维化间歇性肺病 (ILD). 该工具显示了对变化的反应性和预后意义,临床重要差异最小值 (MCID) 为5毫米.
科学领域:
- 肺部医学 肺部医学
- 临床评估 临床评估
- 患者报告的结果
背景情况:
- 视觉模拟尺度 (VAS) 是衡量疾病影响的常用工具.
- 它在间歇性肺病 (ILD),特别是纤维性ILD中的实用性需要进一步验证.
- 了解纤维性ILD中呼吸障碍VAS的临床重要差异 (MCID),反应能力和预后价值至关重要.
研究的目的:
- 在一大批纤维性ILD患者中验证呼吸不良VAS.
- 为了确定MCID,响应能力和呼吸障碍VAS的预后意义.
- 评估呼吸不良的VAS变化与其他已确定的ILD严重程度的相关性.
主要方法:
- 一个潜在的注册表确定了826名纤维性ILD患者.
- 呼吸障碍VAS的有效性通过与验证的问卷 (UCSD SOBQ,KL-15 B&A) 和肺功能测试 (FVC,DLCO) 的相关性来评估.
- 响应得到了定性确认,使用和分布方法计算了MCID,并根据死亡或移植的时间评估了预后意义.
主要成果:
- 呼吸不良VAS变化得分与UCSD SOBQ (r=0.55) 和KL-15 B&A (r=0.44) 显示了中等相关性.
- 基于的MCID估计范围从2.7到4.5毫米,而基于分布的方法产生了12.0毫米.
- 呼吸不良VAS与死亡或移植的时间显著相关 (HR 1.16-1.15,P<0.05).
结论:
- 呼吸障碍VAS是评估纤维性ILD呼吸障碍的有效和响应性的工具.
- 据估计,在纤维性ILD中呼吸不全的VAS中,基于的最小临床重要差异 (MCID) 为5毫米.
- 呼吸不良VAS具有预后意义,有助于评估纤维性ILD患者的结果.
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