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Colloidal precipitates01:09

Colloidal precipitates

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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
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The Colloidal State01:29

The Colloidal State

163
The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called...
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Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy
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用粗粒度,分子尺度模拟对 mAb 体稳定性的计算选.

J Joel Janke1, Charles G Starr1, Jonathan S Kingsbury1

  • 1Biologics Drug Product Development and Manufacturing, Sanofi, Framingham, Massachusetts 01701, United States.

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概括

早期识别稳定的单克隆抗体 (mAbs) 对于开发有效的蛋白质疗法至关重要. 本研究提出了一个计算模型来预测体稳定性,有助于早期的候选药物查和配方.

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科学领域:

  • 蛋白质治疗药物 蛋白质治疗药物
  • 生物制药的发展.
  • 计算生物物理学的计算生物物理.

背景情况:

  • 单克隆抗体 (mAbs) 是重要的蛋白质治疗药物,但它们的发展往往因高度的体不稳定性而受到阻碍.
  • 开发稳定,高度的液体配方对于以患者为中心,以设备为媒介的蛋白质疗法的交付至关重要.
  • 目前用于评估体稳定性的实验方法耗时且资源密集,通常在开发后期进行.

研究的目的:

  • 开发和验证一种有效的计算方法,用于早期查单克隆抗体 (mAbs) 中的体稳定性.
  • 为预测mAb自我相互作用和批量解决方案行为提供一个框架,帮助选择可开发的候选人.
  • 支持早期候选查和晚期蛋白质疗法的配方策略.

主要方法:

  • 粗粒度分子尺度模型的微调,以选氨基酸分辨率的合体稳定性.
  • 开发一个计算框架来分析mAb自我相互作用并预测散装解决方案的行为.
  • 在各种缓冲条件下将计算模型应用于多样化的mAbs集.

主要成果:

  • 该计算模型在氨基酸分辨率下成功选了单克隆抗体 (mAbs) 的合稳定性.
  • 该模型的参数化为评估mAb自我相互作用和预测解决方案行为提供了一个强大的框架.
  • 该方法在增加早期候选查和为蛋白质治疗药物的配方策略提供信息方面表现出实用性.

结论:

  • 对体稳定性的计算查为药物开发早期阶段的实验方法提供了一个有效的替代方案.
  • 开发的分子级建模方法可以识别合稳定的mAbs,促进有前途的治疗候选者的选择.
  • 这种计算策略增强了用于蛋白质治疗的稳定,高度液体配方的开发.