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通过药物代谢的人性化模型加速传染病药物发现和开发

A Kenneth MacLeod1, Kevin-Sebastien Coquelin2, Leticia Huertas3

  • 1Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom.

Proceedings of the National Academy of Sciences of the United States of America
|February 5, 2024
PubMed
概括

人性化小鼠 (8HUM) 通过模仿人类药物代谢来改善药物发现,减少失败并增强临床翻译. 该模型准确地预测药物相互作用和治疗疾病的疗效,加速新药的开发.

关键词:
发现药物的发现.在体内活体模型中的模型.传染病是一种传染性疾病.药理学 药理学 药理学 药理学 药理学翻译研究是翻译研究.

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