在连续工艺下进行Amberlyst-A26-Mediated Corey-Chaykovsky Cyclopropanation的9-基-9H-
Moseen A Shaikh1, Akash S Ubale1, Boopathy Gnanaprakasam1
1Department of Chemistry, Indian Institute of Science Education and Research, Pune, Maharashtra 411008, India.
The Journal of organic chemistry
|February 5, 2024
概括
一种新的连续加工方法使得使用三甲基硫酸和Amberlyst-A26.2的基能直接循环化. 这种高效的科里-查科夫斯基反应产生了有价值的螺旋[cyclopropane-fluorene]和螺旋[cyclopropane-indolinone]衍生物.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
- 过程化学 过程化学
背景情况:
- 科里-查科夫斯基反应是环烯合成的关键方法.
- 开发连续流程流程在效率和可扩展性方面提供了优势.
- 异质催化剂可以简化产品净化和催化剂回收.
研究的目的:
- 开发一种连续流的工艺,用于非结合的直接循环化.
- 在连续系统中利用三甲基硫酸作为甲源.
- 为了高效地合成spiro[cyclopropane-fluorene]和spiro[cyclopropane-indolinone]衍生品,我们使用了以下方法:
主要方法:
- 采用连续流动反应堆系统.
- 使用三甲基硫酸作为甲转移试剂.
- 加入Amberlyst-A26,一个异质基,以促进Corey-Chaykovsky反应.
主要成果:
- 成功地实现了与碳基组不结合的各种基的直接环化.
- 在优秀的产量中从9-基-9H-的前体中合成了spiro[cyclopropane-1,9'-fluorene]衍生物.
- 由3 - 乙烯 - - 2 - 一元前体产生的螺旋[cyclopropane-1,3'-indolin] - 2'- 一元衍生物.
结论:
- 开发的连续流过程对科里-查科夫斯基循环化非常有效.
- 这种方法提供了一个可扩展和高效的途径,以有价值的螺旋环化合物.
- 使用异质基质简化了反应处理,提高了可持续性.
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