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High-Resolution Mass Spectrometry (HRMS)01:15

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The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the sum of the masses of protons and neutrons inside, considering the masses of protons and neutrons as equal. However, the masses of the proton (1.6726 × 10−24 g) and neutron (1.6749 × 10−24 g) are not truly equal. There is a minor error in the expression of atomic masses relative to the simplest atom of hydrogen. For...
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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization IR-MALDESI
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一个多功能查找算法用于绘制pH值和离子含量,使用P MRSI.

Vanessa L Franke1, Johannes Breitling1, Philip S Boyd1

  • 1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

NMR in biomedicine
|February 5, 2024
PubMed
概括

这项研究引入了一种使用31P MRSI.在组织中准确测量pH和 (Mg) 的新方法. 这种方法独立于生理条件而起作用,可以更好地了解疾病状态.

关键词:
31P MRS 是一个非常简单的代码.31P MRSI 的时间表.的含量是多少? 的含量是多少?离子度离子度的离子度.它们的pH值为pH.图像pH值的成像方法

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科学领域:

  • 生物物理学的生物物理.
  • 生物化学 生物化学
  • 医疗成像医学成像

背景情况:

  • -31磁共振光谱成像 (31P MRSI) 使用无机和腺-5'-三酸盐 (ATP) 的化学转移,非侵入性地绘制pH和 (Mg).
  • 对于31P MRSI的常规校准方程通常仅限于生理条件,这对分析具有改变生物化学环境的患病组织提出了挑战.

研究的目的:

  • 开发和验证一种独立于条件的多参数查找算法,用于使用31P MRSI确定pH和Mg.
  • 提高31P MRSI在各种生物化学条件,包括疾病状态中的准确性和适用性.

主要方法:

  • 开发了一个多参数查找算法,同时使用多个可量化的31P光谱特性.
  • 使用9.4 T的114个模型解决方案的测量生成了一个查看表,并使用基于希尔方程的函数通过插值扩展条目.
  • 测定pH和Mg时,应考虑测量不确定性的概率分布,估计最合理的值.

主要成果:

  • 该算法成功地应用于体内3D 31PMRSI数据从健康志愿者的腿部肌肉和质母细胞瘤患者的大脑在7T.
  • 产生的pH和Mg体积图显示了可信的值,并与传统校准方法相比突出了差异.
  • 概念验证证明了算法在现实世界临床和研究场景中的能力.

结论:

  • 拟议的多参数查找算法允许使用31P MRSI独立于条件的pH和Mg的确定.
  • 这种新的方法提高了31P MRSI在研究健康和患病组织中的生物化学参数的可靠性.
  • 这些发现表明,在变化的生化环境条件下,31P MRSI的诊断潜力得到了改善.