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新的设备",旧"的过敏原. 由Dexcom G7葡萄糖传感器引起的过敏接触性皮肤炎
Martin Mowitz1, Sarah Hosseini1,2, Ingrid Siemund1
1Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
Contact dermatitis
|February 5, 2024
概括
两名儿童被诊断出Dexcom G7葡萄糖传感器引起的过敏接触性皮肤炎 (ACD). 传感器中含有异乙烯酸 (IBOA) 和衍生物,它们是已知的过敏原.
科学领域:
- 皮肤病学 皮肤病学
- 过敏学 过敏学
- 材料科学 材料科学 材料科学
背景情况:
- 过敏性接触性皮肤炎 (ACD) 是已知的风险与医疗设备,如葡萄糖传感器和胰岛素.
- 异波尼尔烯酸盐 (IBOA) 和衍生物是这种设备中常见的敏感剂.
研究的目的:
- 记录Dexcom G7 (DG7) 连续葡萄糖传感器引起的第一个ACD病例.
- 识别DG7用户中导致ACD的特定过敏原.
主要方法:
- 从DG7传感器中怀疑有ACD的两个儿科患者进行了补丁测试.
- 测试包括医疗器械系列,科洛变体 (MHR,GHR) 和DG7传感器提取物.
- 气色谱-质谱学 (GC-MS) 分析了DG7提取物对敏感剂的分析.
主要成果:
- 两位患者对IBOA,甘化罗辛酸 (GHR) 和乙醇产生了积极反应.
- 患者1对甲基化罗辛酸 (MHR) 产生反应;患者2对科洛产生反应.
- GC-MS证实DG7传感器提取物中存在IBOA和相关物质.
结论:
- 在这两名患者中诊断的ACD与已知的医疗器械传感器有关.
- 在DG7传感器中存在IBOA和改性,这表明材料安全评估不足.
- 这突显了使用这种新型葡萄糖传感器技术的患者的潜在风险.
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