最近生物宏分子系统的刺激响应 (概念到市场):一项审查
Davinder Singh1, Yashika Sharma2, Divya Dheer3
1Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.
International journal of biological macromolecules
|February 5, 2024
概括
智能药物输送系统为癌症等疾病提供受控释放. 最近的进展侧重于对刺激有反应的纳米粒子,包括双重和多重刺激系统,以改善治疗结果.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 响应刺激的输送系统,或智能药物输送系统,为药物释放提供时空空间控制.
- 对刺激反应材料 (pH,氧化还原,酶,温度) 的进步对于药物输送和组织工程至关重要.
研究的目的:
- 审查最近的纳米颗粒药物输送系统,重点关注对刺激有反应的材料.
- 要突出单个和多个刺激响应的聚合物材料的设计和制备.
主要方法:
- 关于聚合物纳米粒子,树脂分子,基于脂质的纳米粒子和聚合物-药物联合体 (PDCs) 的文献综述.
- 在刺激敏感的纳米载体结构中强调天然和合成聚合物.
- 对双重和多重刺激反应的纳米载体的研究.
主要成果:
- 对刺激敏感的药物纳米颗粒系统显示出增强的体外/体内释放.
- 双重和多刺激响应的天然聚合物纳米载体正在研究改善药物释放.
- 这些系统正在等待临床试验.
结论:
- 响应刺激的纳米载体提供了增强的药物释放概况.
- 生物聚合物刺激敏感系统需要对临床翻译有充分的了解.
- 开发负担得起和对患者友好的智能药物输送产品是目标.
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