基于精确营养的干预措施的潜在机制,用于管理肥胖
Neel H Mehta1, Samantha L Huey2, Rebecca Kuriyan3
1Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States.
Advances in nutrition (Bethesda, Md.)
|February 5, 2024
概括
精准营养 (PN) 使用个人数据来定制肥胖管理的饮食策略. 它考虑了遗传学,生活方式和环境,但公平的实施仍然是一个挑战.
科学领域:
- 营养科学 营养科学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 肥胖和代谢障碍需要个性化的饮食策略.
- 目前的"一刀切"方法是不够的.
- 精准营养 (PN) 提供了一个量身定制的方法.
研究的目的:
- 审查关于开发肥胖PN干预机制的证据.
- 确定影响个人对饮食策略反应的因素.
- 为了与NIH2030营养研究战略计划保持一致.
主要方法:
- 实验室,动物和人类研究的文献综述.
- 包括生物化学和遗传数据,临床试验和公共计划.
- 分析六个关键领域的机制.
主要成果:
- 机制包括遗传倾向,昼夜节律,身体活动,代谢学,肠道微生物组和行为/社会经济因素.
- 单核酸多态和表观遗传修饰影响饮食反应.
- 有限的临床试验证据和实施挑战存在,特别是在资源较少的环境中.
结论:
- PN可以通过解决个体变异和背景来优化肥胖管理.
- 公平的实施和解决系统因素对于PN的成功至关重要.
- 需要进一步的临床试验证据来支持广泛的PN采用.
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