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Updated: Jul 4, 2025

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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对高度可变药物的缩放平均生物等效方法:平衡平衡软限值和EMA的2010年指南 (改善其I型错误控制的一些方法)

Joel Muñoz1, Jordi Ocaña2, Rolando Suárez1,3

  • 1Department of Statistics, University of Concepcion, Concepcion, Chile.

Statistics in medicine
|February 5, 2024
PubMed
概括

对于高度可变的药物,参考尺度平均生物等效 (RSABE) 方法存在I型错误问题. 改进的"平衡" (LO) 方法减少了这些错误,复制的设计显示出更好的稳定性对抗异性.

关键词:
时间间隔包括原则.点估计约束点估计约束缩放的平均生物等价值.

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