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Updated: Jul 4, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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DNA损伤重塑MITF互动组,以增加黑色素瘤的基因组不稳定性

Romuald Binet1, Jean-Philippe Lambert2,3, Marketa Tomkova1,4

  • 1Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford OX3 7DQ, United Kingdom.

Genes & development
|February 5, 2024
PubMed
概括

微相关的转录因子MITF在DNA损伤反应 (DDR) 中具有非转录的作用. 高MITF水平会损害黑色素瘤细胞中的DNA修复,可能增加癌症风险.

关键词:
修复DNA损伤的修复复制DNA复制DNA复制DNA复制E318KK E318KKK E318KKK E318KKK E318KKK E318KK E318KK E318K E318K E318K E318K E318K E318K E318K E318K E318K E318K E318K E318K E318K E318K E318K E318K E318K K美国MITF MITFNBS1 一个国家标准.这就是SUMOylation的作用.同类的重组组合.黑色素瘤是一种黑色素瘤.复制压力是复制的压力.

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