口腔冷却和加热的分离需要TRPM8
Jinrong Li1, Kyle T Zumpano1, Christian H Lemon2
1School of Biological Sciences, University of Oklahoma, Norman, OK 73019.
概括
短暂受体潜在的拉斯8 (TRPM8) 受体对于区分冷静和温暖的口腔温度至关重要. 缺乏TRPM8的小鼠对温和降温的反应受损,影响了它们基于温度的行为.
科学领域:
- 神经科学是一个神经科学.
- 感官生物学 感官生物学
- 身体生理学 身体生理学
背景情况:
- 口腔冷却感觉对于消化和恒温行为至关重要.
- 通过口腔冷却来激活三角体 afferents 上的冷和薄荷受体 TRPM8.
- TRPM8对大脑和对口腔温度的行为反应的确切作用尚不清楚.
研究的目的:
- 研究TRPM8对神经和行为反应对口腔冷却和温暖的影响.
- 在口腔热感受中区分TRPM8-依赖和独立通路的作用.
主要方法:
- 在体内神经生理学记录了野生类型和TRPM8基因缺陷小鼠中三角核尾状神经元的作用潜力.
- 口腔组织冷却和加热以评估神经元反应.
- 一个新的温度控制的液体选择测试测量了行为的反应.
主要成果:
- 野生类型的三角神经元对口腔冷却表现出不同的反应,分为COLD (响应<10°C) 和COOL (响应<30°C) 细胞.
- 缺乏TRPM8的小鼠缺乏COOL细胞,从而损害神经群体对轻度冷却的反应.
- 由于TRPM8缺乏,导致在凉爽的温度范围内产生类似热量的神经活动.
- 与对照组不同的是,TRPM8缺乏的小鼠避免了温暖和温和的冷水.
结论:
- TRPM8输入对于区分冷和温暖的口腔温度至关重要.
- 缺少TRPM8会破坏对温和降温的正常行为反应.
- 其他热受体可能与TRPM8.8一起导致口腔冷却感.
相关概念视频
01:43Thermosensation
30.4K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
30.4K
01:12Mechanically-gated Ion Channels
6.4K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.4K
01:14Assessing Body Temperature - Oral
745
Here are the steps to accurately measure oral temperature using an electronic thermometer:
Step 1:
Start by practicing proper hand hygiene to prevent the spread of microorganisms.
Step 2:
Take the thermometer out of the charging unit, switch it on, and wait for the ready sign.
Step 3:
Gently slide the probe cover until a click is heard. This simple action prevents cross-contamination and ensures the correct placement of the probe cover.
Step 4:
Instruct the patient to open their mouth and place...
Step 1:
Start by practicing proper hand hygiene to prevent the spread of microorganisms.
Step 2:
Take the thermometer out of the charging unit, switch it on, and wait for the ready sign.
Step 3:
Gently slide the probe cover until a click is heard. This simple action prevents cross-contamination and ensures the correct placement of the probe cover.
Step 4:
Instruct the patient to open their mouth and place...
745
01:19Mechanism of heat transfer
1.2K
Understanding heat transfer mechanisms is essential for understanding how our bodies maintain balance in different environmental conditions. When the environment is thermoneutral, the body is in a state of balance, neither using nor releasing energy to maintain its core temperature. However, when the environment is not thermoneutral, the body employs four heat transfer mechanisms to maintain homeostasis: conduction, convection, evaporation, and radiation. These mechanisms facilitate heat...
1.2K
01:14Assessing Body Temperature - Tympanic membrane
581
Assessing tympanic membrane temperature involves using a tympanic membrane thermometer (TMT). Here is a step-by-step guide:
Step 1: Begin by practicing good hand hygiene to prevent the transmission of microorganisms.
Step 2: Turn on the thermometer and wait until the ready sign appears on the screen to ensure accurate measurement.
Step 3: Slide the probe cover in place to prevent cross-contamination.
Step 4: Instruct the patient to tilt their head to the side for comfort and check for cerumen...
Step 1: Begin by practicing good hand hygiene to prevent the transmission of microorganisms.
Step 2: Turn on the thermometer and wait until the ready sign appears on the screen to ensure accurate measurement.
Step 3: Slide the probe cover in place to prevent cross-contamination.
Step 4: Instruct the patient to tilt their head to the side for comfort and check for cerumen...
581
01:11Temperature and Thermal Equilibrium
6.7K
Heat and temperature are essential concepts for everyone every day. The study of heat and temperature is part of an area of physics known as thermodynamics. It is not always easy to distinguish heat and temperature.
The concept of temperature has evolved from the common concepts of hot and cold. The scientific definition of temperature explains more than just our sense of hot and cold. Temperature is operationally defined as the quantity measured with a thermometer. Furthermore, temperature is...
The concept of temperature has evolved from the common concepts of hot and cold. The scientific definition of temperature explains more than just our sense of hot and cold. Temperature is operationally defined as the quantity measured with a thermometer. Furthermore, temperature is...
6.7K