人类轨道前额皮层活动的内记录在自我参考性插曲性和价值自我判断期间
Behzad Iravani1,2,3, Neda Kaboodvand1,3, James R Stieger1,2
1Laboratory of Behavioral and Cognitive Neuroscience, Stanford University, Palo Alto, California 94305.
概括
轨道前皮层 (OFC) 的高频活动在自我参考思维过程中增加. 在积极自我判断期间OFC活动减少可能与抑郁症病理生理学有关.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 临床神经科学 临床神经科学
背景情况:
- 轨道前皮层 (OFC) 在自我参考处理和情绪调节中起着至关重要的作用.
- 了解OFC在自我参考思维过程中的神经动态对于破译其在心理健康状况中的作用至关重要.
研究的目的:
- 调查OFC分区域 (oPFC和vmPFC) 在自我参考的自传陈述和自我判断期间的时间和解剖参与.
- 探索OFC活动,自我参考处理和抑郁症严重程度之间的关系.
主要方法:
- 在患者中从轨道 (oPFC) 和腹中 (vmPFC) OFC进行内脑电图 (iEEG) 记录.
- 在涉及自传记忆和价值自我判断 (SJs) 的任务中分析高频活动 (HFA).
- OFC HFA与神经心理评估中的抑郁症得分的相关性.
主要成果:
- 在自我参考思维过程中,在oPFC和vmPFC中观察到HFA显著增加.
- HFA功率是根据自我参考刺激的含量调节的,vmPFC HFA发作之前是oPFC HFA.
- 阳性SJ期间OFC HFA降低与较高的抑郁症得分有关,而阴性SJ反应不受影响.
结论:
- OFC,特别是oPFC和vmPFC,在自我参考思维过程中积极参与,具有明显的时间动态.
- 这些发现支持这样一个假设:在积极的自我评估过程中神经活动减少,而不是在消极的自我评估过程中增加活动,与抑郁症的病理生理学有关.
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