辅助生殖技术与胎儿缺陷的关联:系统性审查和元分析
Konstantinos Stavridis1, Maria Pisimisi2, Olga Triantafyllidou1
12nd Department of Obstetrics and Gynecology, "Aretaieion" University Hospital, Athens, Greece.
概括
辅助生殖技术 (ART) 怀孕显示出胎儿表现不良的风险增加. 然而,当在单子妊娠中考虑潜在的混因素时,这种关联会减少.
科学领域:
- 生殖医学 生殖医学
- 产科 产科 产科 产科 产科
- 围产期结局的结果
背景情况:
- 辅助生殖技术 (ART) 是全球广泛的临床实践.
- ART与产科和围产期结果的关联仍然是正在进行的研究领域.
- 潜在的风险,包括胎儿形,需要进行彻底的调查.
研究的目的:
- 进行一项元分析,估计ART程序与单独怀孕中的胎儿缺陷之间的相关性.
- 综合现有的关于人工智能孕育与胎儿不良定位之间的关系的证据.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 搜索了五个主要数据库和两个额外的来源,截至2023年5月.
- 使用ROBINS-1评估研究质量,使用GRADE框架评估证据质量.
主要成果:
- 包括11项研究,涵盖3,360,134次分娩.
- 单独怀孕的ART怀孕有1.50倍的错误呈现风险 (95% CI: 1.30, 1.73).
- 调整后的分析显示,风险降低为1.12 (95% CI:1.02,1.23),这表明相关性较弱.
结论:
- 通过ART怀孕的单独怀孕与与自然怀孕相比,胎儿表现不良的风险较高.
- 考虑到潜在的混因素后,观察到的关联被减弱了.
- 需要进一步的研究来阐明导致这种关系的因素.
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