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瘤微环境 ROS/pH级联响应的超分子纳米平台,具有ROS再生特性,用于增强肝细胞癌治疗

Jinfeng Shi^1,2, Yehui Wang³, Yihan Wu¹

¹State Key Laboratory of Southwestern Chinese Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

ACS applied materials & interfaces

|February 5, 2024

概括

这项研究开发了新的超分子纳米药物 (TPL/PBAE_TK@GA NPs) 用于增强肝细胞癌 (HCC) 治疗. 这些纳米粒子改善了药物输送,导致更好的癌症治疗结果.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
药物输送系统药物输送系统

背景情况:

向药物递送在癌症治疗中面临挑战,包括瘤积累,透和不受控制的释放.
肝细胞癌 (HCC) 治疗疗效通常受到这些药物输送效率低下的限制.

研究的目的:

开发一种多功能超分子纳米平台,用于在HCC治疗中增强ptolide (TPL) 的向输送.
设计能够响应瘤微环境 (TME) 的纳米粒子,以控制药物释放和改善细胞吸收.

主要方法:

制造TPL/PBAE_TK@GANP使用主机-客机相互作用和级联响应的共聚物.
利用甘氨酸 (GA) 在HCC组织中进行有针对性的积累.
利用ROS/pH响应元素触发药物释放和增强细胞内化.

主要成果:

TPL/PBAE_TK@GANP在HCC组织中表现出有效的积累.
这些纳米粒子表现出ROS/pH触发的药物释放机制,导致电荷逆转和增强细胞吸收.
这些纳米药物诱导了癌细胞的亡,自和ROS生成,为改善抗HCC治疗创造了积极的反循环.

结论:

开发的多功能超分子纳米药物为克服基于TPL的HCC治疗的局限性提供了一个有希望的策略.
这种方法增强了药物向,释放和细胞内化,从而在体外和体外模型中获得了令人满意的治疗结果.

关键词:

在ROS再生的再生过程中.对于TME的响应性来说,这是非常重要的.细胞亡和自的发生.这是一个超分子纳米平台.类三类化物

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