维生素D缺乏和便失禁之间的关联
Leila Neshatian1, Gabrielle Grant2, Nielsen Fernandez-Becker1
1Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
Neurogastroenterology and motility
|February 5, 2024
概括
便失禁 (FI) 患者的维生素D缺乏率更高,整体医学并发症增加. 这表明低维生素D水平与便失禁之间存在联系,需要进一步调查潜在的因果因素,如脆弱性.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 维生素D对于肌肉骨健康至关重要.
- 便失禁 (FI) 是一种影响生活质量的疾病.
- 维生素D缺乏症和FI之间的关系尚不清楚.
研究的目的:
- 调查FI患者中维生素D缺乏症的流行情况.
- 为了确定FI患者是否有更高的并发性疾病病率.
- 评估维生素D缺乏与FI发病率之间的关联.
主要方法:
- 2017-2022年电子健康记录的回顾性分析.
- 包括100,111名成年人 (18-90岁) 的25-氧维生素D水平.
- 考克斯比例危险生存分析和倾向性得分匹配被使用.
主要成果:
- 患有FI的患者 (1.2%的队列) 更有可能是女性,白人,老年人和吸烟者.
- 在FI患者中,维生素D缺乏率显著增加 (7.14%与4.45%相比).
- FI患者的查尔森并发症指数得分较高,胃肠道并发症增加,包括便秘,IBS和腹.
- 维生素D缺乏与更高的FI新诊断率有关 (HR 1.9).
结论:
- 便失禁的患者表现出更高的维生素D缺乏率和整体发病率的增加.
- 这些发现表明,维生素D缺乏和便失禁之间存在潜在的联系.
- 建议进行进一步的研究,以探索脆弱性和医疗并发症在这种关联中的作用.
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