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皮囊甲状腺癌中的KLK7,KLK10和KLK11:生物信息分析和实验验证

Tao Ni¹, Ru-Hua Zhao², Jing-Fang Wu²

¹Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.

Biochemical genetics

|February 5, 2024

概括

这项研究确定了Kallikrein相关的酶 (KLKs) 7,10和11作为乳头甲状腺癌 (PTC) 的关键基因. 它们的高表达与瘤进展和低生存率相关,表明它们是潜在的生物标志物和PTC的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

乳头甲状腺癌 (PTC) 研究已经确定了许多基因,但关键的基因仍未被发现.
了解基因表达,突变和临床意义对于有针对性的PTC疗法至关重要.

研究的目的:

调查卡利克林相关酸酶 (KLKs) 家族基因在乳头甲状腺癌 (PTC) 中的作用.
确定用于精确PTC治疗的新型分子标记物和治疗点.

主要方法:

使用生物信息学工具 (GEPIA,Kaplan-Meier Plotter,LinkedOmics,GSCA,Timer,Cluego) 对KLK基因表达,突变和临床意义的全面分析.
功能性试验评估KLK7,KLK10和KLK11对PTC细胞增殖,迁移和入侵的影响.
与瘤阶段和生存数据的相关性分析.

主要成果:

在甲状腺癌中,KLK7,KLK10,KL11和KLK13的mRNA水平显著升高,而KLK1,KLK2,KLK3和KLK4则下降.
KLK2,KL7-12和KLK15的表达与瘤阶段相关.
KLK4,KL5,KL7-12和KLK14的表达水平与甲状腺癌患者的整体存活率有关.
KLK7,KLK10和KLK11与与癌症有关的途径和免疫细胞透有关.
沉默KLK7,KLK10和KLK11抑制了PTC细胞的生长,迁移和入侵.

结论:

KLK7,KLK10和KLK11在PTC表达显著增加,并与瘤进展和侵入性有关.
这些KLK基因可以作为PTC患者识别的有价值的分子标记.
在PTC治疗中,KLK7,KLK10和KLK11代表了精准医学的潜在预后指标和治疗目标.

关键词:

功能功能功能功能与卡利克林相关的酸酶.乳头甲状腺癌是一种乳头甲状腺癌.在TCGA中,TCGA就是TCGA.

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