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短期高热量碳水化合物负载通过诱导FGF21增加了外科手术应激弹性
Thomas Agius1,2,3, Raffaella Emsley1, Arnaud Lyon1
1Department of Vascular Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Nature communications
|February 5, 2024
概括
手术前的碳水化合物负载增加了卡路里摄入量,减少了蛋白质摄入量,促进了纤维细胞生长因子21 (FGF21),以防止手术压力和伤害.
科学领域:
- 代谢和应激反应
- 外科手术术后护理 术后护理
- 伤害和保护的分子机制.
背景情况:
- 饮食限制可以增强对手术压力的抵抗力.
- 目前的外科手术期间的方案建议在手术前增加碳水化合物,以改善恢复.
- 关于碳水化合物负载在手术环境中的影响的临床前数据有限.
研究的目的:
- 研究碳水化合物负载对外科手术应激反应的临床前影响.
- 阐明碳水化合物负载的保护作用背后的分子机制.
- 确定纤维细胞生长因子21 (FGF21) 在碳水化合物负载介导保护中的作用.
主要方法:
- 小鼠接受了一周的液体碳水化合物加载.
- 手术压力模型包括脏和肝脏缺血-再输血损伤.
- 研究了氨基酸添加回和FGF21删除对保护的影响.
- 分析了包括综合应激反应和氧化代谢在内的分子途径.
主要成果:
- 碳水化合物负载降低了固体食物摄入量,同时在小鼠中几乎翻了一番总热量摄入量.
- 碳水化合物负载增加了肝纤维细胞生长因子21 (FGF21) 表达,独立于热量摄入.
- 在小鼠中,FGF21介导的保护对和肝缺血-再输液损伤.
- 在不同性别和年龄段观察到保护,并被氨基酸添加回或FGF21删除所阻止.
结论:
- 手术前的碳水化合物加载促进了蛋白质稀释,导致FGF21增加.
- 通过综合应激反应和氧化代谢,FGF21诱导对通过综合应激反应和氧化代谢保护手术应激至关重要.
- 这些发现支持在手术前使用碳水化合物充满饮料,并突出FGF21的保护作用.
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