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新生儿尿路感染新生物标志物的度

Maria Jebbia^1,2, Sudipti Gupta^1,3, Brett G Klamer^4,5

¹The Kidney and Urinary Tract Center at Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, USA.

Scientific reports

|February 5, 2024

概括

抗微生物 (AMP),如RNase 7和Beta Defensin-1,存在于新生儿尿液中. 它们的度随着妊娠年龄的增加而下降,这有可能改善新生儿的尿路感染 (UTI) 诊断.

科学领域:

新生儿医学新生儿医学
临床诊断临床诊断临床诊断
生物化学生物化学

背景情况:

尿路感染 (UTI) 在住院新生儿中很常见,但目前的诊断方法有局限性.
现有的尿路感染诊断涉及侵入性样本采集,风险污染,缺乏标准化定义.
抗微生物 (AMP) 显示为儿童尿路感染诊断的新生物标志物具有前途.

研究的目的:

为了确定新生儿尿液中Ribonuclease 7 (RNase 7) 和Beta Defensin-1 (BD-1) 的基线度.
确定AMP度与新生儿妊娠年龄 (GA) 之间的关系.
为了确定新生儿尿液中AMP的基准值,以潜在的诊断用途.

主要方法:

从IV级新生儿重症监护病房的新生儿收集尿液样本.
测量了RNase 7和BD-1的度,并将其正常化为尿液中的肌素 (UCr).
分析了数据以将AMP水平与妊娠年龄和出生体重相关联.

主要成果:

从怀孕22周开始,新生儿尿液 (n=66) 中检测到RNase 7和BD-1.
随着妊娠年龄和出生体重的增加,尿液中的AMP度显著下降.
中位数RNase 7/UCr和BD-1/UCr值分别为271 ng/mg和116 ng/mg,明显的GA依赖变化.

结论:

确定新生儿尿液中RNase 7和BD-1的基线度.
发现AMP水平与妊娠年龄之间存在显著的反向关系.
这些发现对于开发基于AMP的诊断来改善新生儿尿路感染检测至关重要.

关键词:

支持的营销策略 (AMPs)抗微生物是一种抗微生物.生物标志物生物标志物新生儿是一种新生儿.这是一个UTI,UTI是UTI.尿路感染尿路感染

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