结肠直肠癌的预诊断症状与解剖癌症部位相关
Nicole L Briggs1,2, Mimi Ton3,4, Rachel C Malen4
1Department of Epidemiology, University of Washington School of Public Health, UW Box #351619, 3980 15th Ave NE, Seattle, WA, 98195, USA. nbriggs@uw.edu.
BMC gastroenterology
|February 5, 2024
概括
结肠直肠癌 (CRC) 的症状,如便中的血液与瘤的位置有关,特别是在早期出现的CRC. 识别这些迹象有助于及时诊断50岁以下的患者.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 结肠直肠癌 (CRC) 诊断在未达到推查年龄的患者中经常因忽视的症状而延迟.
- 在CRC患者的诊断前症状可以表明瘤的位置和影响预后.
- 早期发病的CRC (50岁以下) 越来越令人担忧,需要更好的诊断策略.
研究的目的:
- 调查患者诊断前症状与结直肠癌解剖部位之间的关联.
- 确定这种关联是否根据CRC诊断时的年龄不同,特别是在早期发病的情况下.
主要方法:
- 通过SEER癌症登记册识别的626名CRC患者的基于人口的研究利用了医学抽象.
- 使用后勤回归来计算症状-解剖部位关联的几率比率和置信区间.
- 根据诊断时的年龄进行了分层分析,将早期发病定义为50岁以下.
主要成果:
- 便中的血液与直肠癌有显著的关联 (OR 4.37),而便的变化与直肠癌有关 (OR 1.78).
- 结肠癌患者更有可能出现腹痛 (OR 0.30),贫血 (OR 0.40),或没有症状 (OR 0.68).
- 便中的血液与直肠瘤之间的关联在早期发病的CRC患者中更为强烈 (OR 6.48).
结论:
- 诊断前的红旗症状与结直肠癌的解剖位置相关.
- 这些发现可以指导胃肠科医生进行分类护理和早期CRC评估,特别是对于日益增长的早期发病病例.
- 了解症状与部位之间的关联对于改善结直肠癌的诊断准确性和患者治疗结果至关重要.
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