评估TNF-α-1031 T/C多态性与口腔平坦菌病之间的关联
Mohammad Hesam Marabi1,2, Hamid Reza Mozaffari3, Haniyeh Ghasemi1,2
1Student Research Committee, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
BMC oral health
|February 5, 2024
概括
瘤亡因子-α (TNF-α) 基因的-1031 T/C多态性与伊朗人口腔平菌 (OLP) 的风险增加有关. 这种基因变异,特别是C等位基因,可能会增加患上OLP的易感性.
科学领域:
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
- 口腔医学是指口腔医学.
背景情况:
- 口腔平坦 (OLP) 是一种影响口腔上皮细胞的自身免疫性疾病.
- 据了解,这是一种T细胞介导的疾病.
- 遗传因素可能会影响OLP的易感性.
研究的目的:
- 调查TNF-α基因-1031 T/C多态化 (rs1799964) 与OLP风险和严重程度之间的关联.
- 为了分析伊朗人口中的这种遗传联系.
主要方法:
- 从100名OLP患者和100名健康对照者的唾液样本中提取了DNA.
- 使用PCR-CTPP方法进行了瘤缩因子-α (TNF-α) -1031 T/C多态的基因型鉴定.
- 使用SPSS软件进行了统计分析.
主要成果:
- 与对照组 (36%) 相比,在OLP患者中观察到TNF-α-1031 T/C多态的C等位基因的显著更高的流行率 (53%).
- 携带C等位基因与明显增加的OLP风险相关 (OR=1.64,p=0.04).
- 这种多态化与OLP的严重程度之间没有发现显著的关联.
结论:
- 这项研究提供了证据证明TNF-α-1031 T/C基因多态化在伊朗人口中OLP易感性中的作用.
- 这种C等位基因可能有助于增加对OLP的敏感性.
- 进一步的研究是有必要的,以探索精确的机制.
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