基于心血管和脏并发症的特定种族血压值:英国生物银行的一项前性研究
Donghan Su1, Huanhuan Yang1, Zekun Chen1
1Vanke School of Public Health, Tsinghua University, Beijing, China.
BMC medicine
|February 5, 2024
概括
英国少数民族群体需要新的血压值. 特定于种族的缩性血压 (SBP) 切断可以改善高血压管理,减少心血管和脏并发症.
科学领域:
- 心血管研究的心血管研究.
- 腎臟醫學 腎臟醫學
- 公共卫生 公共卫生
背景情况:
- 目前的高血压指南可能无法准确评估英国非白人人口的心血管和风险.
- 需要质疑现有的高血压值对不同种族群体的适当性.
研究的目的:
- 为英国少数民族群体建立特定种族的静脉压 (SBP) 切断值.
- 评估这些种族特异性切断值在预测心血管和脏不良结果方面的有效性.
主要方法:
- 分析了英国生物库4444418名参与者的数据,这些参与者来自白人,南亚人,黑人加勒比人和黑人非洲人群.
- 用于确定种族特异性SBP值的复合结果 (动脉样性心血管疾病,心力衰竭,慢性病) 的Poisson回归模型.
- 模型根据临床,社会人口统计学和行为因素进行调整;使用人口归因分数 (PAF) 评估绩效.
主要成果:
- 南亚人显示在任何给定的SBP中,复合结果的预测发病率最高.
- 140毫米升的白人个人等价风险的特定种族SBP值为南亚人123毫米升,黑人加勒比人156毫米升,黑人非洲人165毫米升.
- 与指导值相比,特定种族值改善了南亚人和黑人非洲人的复合结果的预测并增加了PAF.
结论:
- 指南推的血压值可能不准确地估计了黑人和南亚人群的风险.
- 实施特定种族的SBP值可以提高风险预测和优化高血压管理.
- 这种方法旨在减少心脏病并发症的种族差异.
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