战斗喷气式飞行员的训练飞行对气道功能的参数,扩散能力和系统氧化应激的影响,以及它们与飞行参数的关联
Janina Bojahr1,2,3, Rudolf A Jörres4, Angelika Kronseder4
1Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), University Hospital, LMU Munich, Munich, Germany. janina.bojahr@gmail.com.
European journal of medical research
|February 5, 2024
概括
战斗机飞行员训练飞行导致肺功能暂时减少,氧化应激标志物增加. 这些生理效应虽然没有临床意义,但表明现代喷气式飞机训练对飞行员健康的影响.
科学领域:
- 航空航天医学 航空航天医学
- 肺部生理学 肺部生理学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 战斗机飞行员面临来自Gz力量的生理压力,正压呼吸和氧气支持.
- 现实世界训练飞行对肺功能和氧化应激的影响仍在调查中.
研究的目的:
- 评估欧洲战斗机台风训练飞行后战斗机飞行员的肺功能和全身氧化应激.
- 为了确定飞行参数和生理变化之间的潜在相关性.
主要方法:
- 肺部扩散能力 (DLCO,DLNO),气膜体积 (VA) 和每体积扩散能力 (KCO,KNO) 在飞行前后进行测量.
- 为了评估氧化应激,分析了部分呼出的氧化 (FeNO) 和尿中的8-基-2'-脱氧氨 (8-OHdG).
- 混合ANOVA模型被用于对35名飞行员和145次飞行的数据进行统计分析.
主要成果:
- 在飞行后观察到DLNO,DLCO,KNO,KCO和VA的显著减少 (p < 0.001).
- FeNO下降了11.1%,尿液中的8-OHdG/肌素比率增加了15.7%.
- 较长的飞行时间和较高的高度更明显地减少了飞行时间,但在休息后恢复了基线值.
结论:
- 观察到的扩散能力的减少表明,乳腺扩散和扩散屏障发生了变化,毛细血管血液体积没有发生变化.
- 降低FeNO表明支气管粘膜刺激或局部氧化应激.
- 增加的8-OHdG表明系统性氧化应激,证明训练飞行的生理影响.
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