甲福明使用与糖尿病结核病患者死亡率之间的关系:一项全国性队列研究
Eunki Chung1, Dawoon Jeong2, Jeongha Mok3
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
The Korean journal of internal medicine
|February 5, 2024
概括
结核病和糖尿病患者使用甲福明可显著降低全因死亡率. 这表明甲福明可能是这种高风险人群的有益辅助疗法.
科学领域:
- 医学研究 医学研究
- 临床药理学 临床药理学
- 流行病学 流行病学
背景情况:
- 结核病 (TB) 和糖尿病 (DM) 的患者面临更高的死亡率.
- 甲胺是一种潜在的宿主导结核病治疗方法.
- 调查甲胺对结核病和DM患者结局的影响至关重要.
研究的目的:
- 评估甲福明在改善结核病和DM同时存在的患者的预后方面的有效性.
- 为了确定甲福明的使用是否会降低这一患者群的全因死亡率.
主要方法:
- 使用国家监测和健康数据库 (2011-2017) 进行的回顾性队列研究.
- 通过使用甲福明 (≥28天) 进行分类的患者.
- 用于分析所有原因死亡率的双倾向得分调整和多变量考克斯比例危险模型.
主要成果:
- 在结核病治疗期间,甲胺使用者的全因死亡率明显降低 (9.5%与12.4%,p < 0.01).
- 使用甲胺与所有原因死亡的风险降低有关 (aHR 0.76,95% CI 0.67-0.86,p < 0.01).
- 在甲福明使用者中观察到非结核病相关死亡人数显著减少.
结论:
- 梅特福林的使用与结核病和DM患者全因死亡率的降低有关.
- 甲胺显示出作为TB-DM共患患者的辅助疗法的潜力.
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