在SARS-CoV-2疫苗接种后,在青少年实体器官移植接受者中,抗尖端抗体的耐用性
John McAteer1,2, Divya D Kalluri3, Rivka R Abedon3
1Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Pediatric transplantation
|February 6, 2024
概括
在接受器官移植的青少年中,抗体水平在接种了三剂COVID-19疫苗后的6个月内保持持久. 一些参与者经历了免疫力下降或突破性感染,突出显示了持续监测的必要性.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 移植 移植 移植 移植
背景情况:
- 青少年固体器官移植接受者 (aSOTRs) 在接种了三剂COVID-19 mRNA疫苗后显示出高初始血清转换.
- 在aSOTRs中,疫苗接种后超过三个月的长期抗体耐用性尚未得到充分证实.
研究的目的:
- 在aSOTRs中,在第三剂BNT162b2 mRNA疫苗接种后六个月评估抗体反应.
- 评估这种脆弱人群中的长期抗体耐用性和突破性感染.
主要方法:
- 观察性,多中心队列研究分析了抗SARS-CoV-2尖端蛋白受体结合域 (RBD) 抗体标位.
- 在接种第三剂疫苗后的1,3个月和6个月收集的样本 (D3).
- 在D3.3后12个月内调查突破性感染的参与者.
主要成果:
- 所有34名参与者在D3.3后的6个月内都保持了积极的抗RBD抗体标位.
- 抗体标位在三到六个月之间变化,其中29%的抗体水平下降.
- 12%的人在D3.3后六个月内报告了突破性感染.
结论:
- 三剂SARS-CoV-2mRNA疫苗在aSOTRs中提供了长达六个月的抗体耐用性.
- 人口和移植特征没有预测抗体减弱.
- 突破性感染发生了,可能是由于像Omicron这样的免疫逃避变种.
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