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Updated: Jul 4, 2025

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微生物驱动的合成和化Neohesperidin Dihydrochalcone:生物转化过程和可行性调查

Yucong Zou¹, Xiaofeng Li¹, Xuan Xin²

¹School of Food Science and Engineering, South China University of Technology, Wushan Road 381, Guangzhou, Guangdong 510640, China.

Journal of agricultural and food chemistry

|February 6, 2024

概括

一种新的酵母介导化方法可以有效地合成新素二甲 (NHDC). 这一过程与水解相结合,为废物中有价值的化合物提供了安全,经济高效,单一的生物合成方法.

科学领域:

生物技术是生物技术.
合成生物学合成生物学
绿色化学绿色化学

背景情况:

新素二甲 (NHDC) 是一种有价值的甜味剂.
传统的NHDC化学合成在效率和安全方面面临挑战.
利用生物系统为化合物合成提供了一个可持续的替代方案.

研究的目的:

开发一种用于NHDC合成的新型酵母介导化.
建立一个全细胞催化水解,以将NHDC转化为甜味剂.
为高价值化合物创建一个一,两步生物合成平台.

主要方法:

酵母介导的NHDC前体的生物化.
使用*Aspergillus niger*进行NHDC的全细胞水解.
一级联生物合成,结合化和水解.
优化反应条件,包括催化剂,系统组件和葡萄糖添加.

主要成果:

通过酵母介导的化实现了NHDC的高产量 (超过83%).
成功地将NHDC化成素二甲-7-O-葡萄糖化物 (HDC-G) 和素二甲 (HDC).
与化学方法相比,证明了更高的反应稳定性,更高的安全性和成本效益.

结论:

使用酵母生产NHDC的新高效途径.
为有价值的化合物建立了一个灵活的单级联生物合成平台.
提供一种可持续和安全的方法来利用果加工废物.

关键词:

的可行性和可行性.新西胺二甲基.新鲜的甜味剂新鲜的甜味剂全细胞催化水解的催化水解.在酵母中介的酵母化中.

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