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在患有狼性炎的患者中研究微RNA-124

Mostafa Abdelsalam¹, Maysaa El Sayed Zaki², Nermin Youssef Abo El-Kheir²

¹Department of Internal Medicine, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt and Nephrology and Dialysis Unit, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Endocrine, metabolic & immune disorders drug targets

|February 6, 2024

概括

与健康个体相比,狼性炎患者的microRNA-124水平显著下降. 较低的miR-124水平与狼性炎的临床和血清学发现相关,表明其作为生物标志物的潜力.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

狼性炎 (LN) 显著增加死亡风险.
高水平的MicroRNA-21和MicroRNA-155是活性LN的危险因素.
微RNAs显示出作为临床LN阶段的诊断生物标志物的希望.

研究的目的:

在狼性炎患者和健康对照人群中量化miR-124水平.
在LN患者中调查miR-124水平和生物化学标记之间的相关性.

主要方法:

一项涉及50名LN患者和50名健康对照者的病例控制研究.
实时聚合酶链反应 (PCR) 用于测量miR-124水平.
确定了系统性红斑狼 (SLE) 的血清标志物.

主要成果:

与对照组相比,狼性炎患者的miR-124水平 (1.193 ± 0.56) 显著降低 (3.36 ± 0.50,p <0.001).
与没有肌肉表现的患者 (1.02 ± 0.5) 相比,与没有肌肉表现的患者 (1.47 ± 0.5,p = 0.005) 相比,在LN患者中观察到miR-124的显著下降.

结论:

在狼性炎患者中,microRNA-124的下调显著.
miR-124水平与SLE的临床和血清学发现相关.
miR-124可以作为一种非侵入性生物标志物,用于监测LN治疗反应,预测复发,并评估疾病活性或慢性.

关键词:

这是一个微型RNA.系统性狼是一种系统性狼.生物标志物生物标志物微型RNA-12424是什么意思炎是一种神经炎症.血清学发现结果

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...