针对SARS-CoV-2的常见药用植物的主要抗病毒植物化合物的系统审查
Suvendu Ghosh1, Partha Sarathi Singha2, Lakshmi Kanta Das2
1Department of Physiology, Hooghly Mohsin College, Chinsura, Hooghly 712 101, West Bengal, India.
Medicinal chemistry (Shariqah (United Arab Emirates))
|February 6, 2024
概括
药用植物提供强大的抗病毒化合物,用于开发新药来对抗新出现的病毒,如SARS-CoV-2. 这些天然化合物为治疗COVID-19的合成药物提供了具有成本效益和安全性的替代品.
科学领域:
- 植物化学 植物化学
- 病毒学 病毒学
- 药物发现 药物发现 药物发现
背景情况:
- 全球越来越多的病毒感染和抗菌素耐药性对公众健康构成重大威胁.
- 新出现的传染病,以SARS-CoV-2引起的COVID-19大流行为例,需要新的治疗策略.
- 环境变化和人类活动增加了新的病毒爆发的风险.
研究的目的:
- 探索药用植物中的植物化合物作为抗病毒剂的潜力.
- 确定用于开发针对病毒的新型药物配方的分子,包括SARS-CoV-2.
- 调查基于天然产品的解决方案,以对抗病毒性疾病.
主要方法:
- 使用in silico工具选来自各种植物生物多样性的植物化合物.
- 确定具有潜在抗病毒活性的有希望的分子.
- 对植物衍生化合物的评估,以使其在结构上转化为生物活性衍生品.
主要成果:
- 在基查中,确定了几种植物化合物作为针对SARS-CoV-2的强有力的分子.
- 这些天然化合物对开发有效的COVID-19治疗方法充满希望.
- 来自植物的分子在对抗高度突变的病毒方面表现出显著的潜力.
结论:
- 植物化合物为开发具有成本效益的抗病毒药物配方提供了宝贵的资源.
- 从药用植物中提取的天然化合物通常比合成替代品具有较少的副作用.
- 可以利用本土植物生物多样性来制造强大的治疗药物来对抗病毒感染.
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