在日本使用保险索赔数据库的牛皮病患者的现实世界生物治疗模式和医疗保健资源利用情况
Celine Miyazaki1, Junya Masuda2, Mateo Delclaux Rodriguez-Rey3
1Value, Evidence and Access Department, Janssen Pharmaceutical K.K., Tokyo, Japan.
The Journal of dermatological treatment
|February 6, 2024
概括
在日本,对牛皮的真实世界生物使用显示出不断演变的模式. 药物依赖性因药物而异,而经验丰富的生物药物患者的医疗保健资源利用率和成本较高.
科学领域:
- 皮肤病学 皮肤病学
- 药物经济学 药物经济学
- 现实世界的证据.
背景情况:
- 牛皮的治疗正在推进新的生物疗法.
- 了解日本现实世界的生物使用至关重要.
研究的目的:
- 在日本分析牛皮的生物治疗模式.
- 评估医疗保健资源利用率 (HCRU) 和成本.
- 评估患者对生物疗法的坚持.
主要方法:
- 对1,614名患有牛皮生物索赔的患者进行了回顾性研究 (2016-2020年).
- 使用描述性统计数据分析治疗模式,HCRU和成本.
- 评估坚持率和影响它们的因素.
主要成果:
- 干白素-17和瘤坏死因子α抑制剂是常见的. 对于治疗切换来说,IL-23抑制剂是最受青的.
- 平均坚持率为80.1%,在生物类之间存在差异. 英弗利克西马布和IL-23抑制剂表现出最好的粘附性.
- 生物经验丰富的患者的高HCRU和成本相比,生物无经验患者的高HCRU和成本被观察到.
结论:
- 变量依从性需要改善不同生物制剂的治疗管理策略.
- 有生物学经验的患者可能会面临由于疾病进展和治疗切换而增加的医疗负担.
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