序列式的ortho-/meta-C-H功能化N-托西尔-胺基用于合成多功能化基
Martin Vuagnat1, Philippe Jubault1, Tatiana Besset1
1INSA Rouen Normandie, Univ Rouen Normandie, CNRS, Normandie Univ, COBRA UMR 6014, Rouen F-76000, France. tatiana.besset@insa-rouen.fr.
这项研究引入了一种创新的方法,通过选择性C-H功能化来创建复杂的多功能化. 该过程在单个步骤中有效地形成碳-氧和碳-化合物键,产生有价值的化学中间体.
科学领域:
- 有机化学 有机化学
- 合成方法论 合成方法论
- 催化剂是一种催化剂.
背景情况:
- C-H功能化是合成复杂有机分子的关键策略.
- 开发选择性和高效的方法来进行多功能化烯合成仍然是一个挑战.
研究的目的:
- 开发一种新的单电位顺序正义/元CH功能化策略.
- 从简单的碳酸衍生物中合成非常理想的多功能化.
主要方法:
- 采用了选择性的单电位序列C-H功能化反应.
- 使用随时可用的碳酸衍生物作为起始材料.
- 优化了用于同时形成C-O和C-素键的轻度反应条件.
主要成果:
- 在单个中实现了选择性的正统和元CH功能化.
- 成功合成了12个多功能化的例子,产量高达75%.
- 证明了同时形成C-O和C-素键.
结论:
- 开发的方法为有价值的多功能场馆提供了一条有效的途径.
- 合成的产品作为进一步化学转换的多功能构建模块.
- 这些产品的实用性通过后功能化和在梅地格林尼德合成中的应用得到证实.
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