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对于SARS-CoV-2医院消毒的方法,体外观察观察
Dora E Corzo-Leon1,2, Hadeel Mohammed Abbood1,3, Rosa A Colamarino1
1School of Medicine Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, Scotland, UK.
乙醇和赫西丁等化学消毒剂显示出强烈的SARS-CoV-2无活化,与臭氧化水不同. 紫外线-C (UVC) 辐射,特别是UVC-254nm,表现出一些有效性,但与化学方法对抗COVID-19变种不匹配.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 环境健康 环境健康
背景情况:
- 随着COVID-19大流行,化学消毒剂的使用增加,引发了职业安全方面的担忧.
- 对于医疗保健机构,正在探索紫外线C (UVC) 辐射和臭氧化等替代消毒方法.
- 在医疗保健中缺乏UVC和臭氧使用的标准标准.
研究的目的:
- 为了比较常见化学消毒剂和新型UVC照射方法的杀菌效果.
- 为了评估70%乙醇,二二酸酸盐 (NaDCC),,臭氧化水,UVC-222nm和UVC-254nm对SARS-CoV-2变种的有效性.
- 评估暴露时间对UVC消毒效果的影响.
主要方法:
- 在三种SARS-CoV-2变种 (α,β,gamma) 上进行了体外无活化试验.
- 测试的化学剂包括乙醇 (70%),NaDCC (100-1000 ppm),素 (0.5-2%) 和臭氧化水 (7 ppm).
- 使用UVC-254nm和UVC-222nm灯的UVC辐射被测试,暴露时间有所变化 (6秒和3分钟).
主要成果:
- 乙醇,NaDCC和赫西丁实现了>3日志病毒不活化.
- 臭氧化水显示出最小的杀毒效应 (<1日志不活化).
- 紫外线-254nm将病毒活性降低1-5日志,更长时间暴露 (3分钟) 会产生更高的无活化. 紫外线-222nm没有显示时间依赖的无活化.
结论:
- 传统的化学消毒剂,包括0.5%的赫西丁,与UVC辐射相比,对SARS-CoV-2变种表现出优越的杀毒活性.
- 紫外线辐射,特别是紫外线-254nm,显示出一些疗效,但与化学剂的疗效不匹配.
- 臭氧化水在测试方法中表现出最少的杀毒活性.
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