在两个前性研究中,产前金属暴露和儿童社会响应度量得分在2个前性研究中
Emma X Yu1, John F Dou2, Heather E Volk3,4,5
1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Environmental health insights
|February 6, 2024
概括
对 (Pb) 和 (Hg) 等金属的产前暴露与儿童的社会反应没有明确的关联. 需要进一步的研究来了解金属混合物对自闭症谱系障碍 (ASD) 风险的潜在异质影响.
科学领域:
- 环境健康 环境健康
- 神经发育障碍 神经发育障碍
- 毒理学 毒理学 毒理学
背景情况:
- 产前暴露于环境金属是儿童神经发育结果的潜在风险因素.
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,具有多因素的病因.
- 在怀孕期间调查特定的金属暴露对于了解早期对儿童发育的影响至关重要.
研究的目的:
- 检查产前暴露于 (Pb), (Hg), (Mn) 和 (Se) 对儿童社会反应能力的联合和个人影响.
- 评估尿液金属混合物与36个月龄的儿童的社会反应量表 (SRS) Z-分数之间的关联.
- 探索两个高风险自闭症群体内的金属-金属和金属-儿童相互作用的潜在异质性.
主要方法:
- 利用了早期自闭症风险纵向调查 (EARLI) 和婴儿学习早期迹象 (MARBLES) 研究中的自闭症风险标志物的数据.
- 在怀孕期间收集的母亲尿液样本中测量金属度 (Pb,Hg,Mn,Se).
- 采用贝叶斯核机器回归和线性回归模型,调整相关的共变量,以分析金属-SRS得分关联.
主要成果:
- 在36个月的整体产前金属混合物和儿童SRS Z-分数之间没有明确的单调关联.
- 混合物中的单个金属,包括 (Pb),与SRS Z-score没有明显的关联,所有可信的间隔包括零值.
- 观察到金属混合物和个体金属对儿童性别和研究队列的影响的潜在异质性.
结论:
- 该研究没有找到明确的证据,将产前暴露于被调查的金属混合物或单个金属与儿童的社会反应联系起来.
- 结果表明,产前金属暴露对社会发展的影响可能是复杂的,并可能因儿童个体特征和环境环境而异.
- 建议采用更大的样本大小和进一步调查,以阐明产前金属暴露与ASD等神经发育结果之间的细微关系.
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