在囊性纤维化患者中通过移植状态评估鼻微生物学:一项匹配的队列研究
Ranjani Somayaji1,2,3,4, Christina S Thornton1,2,3, Nicola Acosta1
1Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine University of Calgary Calgary Canada.
OTO open
|February 6, 2024
概括
在患有囊性纤维化 (PwCF) 和肺移植后的PwCF患者之间,鼻腔和呼吸道微生物组不同. 了解这些微生物差异是管理PwCF中鼻疾病的关键.
科学领域:
- 微生物学 微生物学
- 肺部病理学 肺部病理学
- 移植手术 移植手术
背景情况:
- 鼻腔疾病在患有囊性纤维化 (PwCF) 的人群中很常见,并且可以在肺移植接受者中携带感染.
- 在PwCF中的鼻微生物组及其与慢性鼻炎 (CRS) 的联系尚不清楚.
研究的目的:
- 调查PwCF和肺移植后PwCF (pTxPwCF) 中的鼻和下呼吸道微生物组组成.
- 在这些患者群体中探索微生物组和CRS之间的关联.
主要方法:
- 一项前性研究包括31个匹配的PwCF和pTxPwCF.
- 鼻和唾液被收集用于16S rRNA基因测序.
- 使用SNOT-22和隆德-麦凯分数来评估CRS.
主要成果:
- 气道微生物群主要由 Pseudomonas,Haemophilus,Staphylococcus,Streptococcus 和 Fusobacterium 占据主导地位.
- 微生物组多样性 (α-多样性) 在pTxPwCF中对于唾液和鼻样本都较低.
- 根据移植状态,液样本之间的微生物组组成 (β-多样性) 显著不同.
结论:
- 鼻和气道微生物组在PwCF和pTxPwCF中显示出不同的模式,尽管主要的细菌是相似的.
- 需要进一步的研究来将微生物群状况与PwCF中优化鼻病管理的临床结果联系起来.
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