重度抑郁症患者的灰质异常与自杀企图:年龄特定差异的系统审查
Ziwen Chen1, Tao Xu1, Qifu Li2
1Department of Acupuncture and Moxibustion, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Heliyon
|February 6, 2024
概括
大型抑郁症 (MDD) 与自杀企图中的结构性大脑变化因年龄而异. 老年人和中年患者显示灰质减少,而青少年在某些区域显示体积增加,有助于预测自杀风险.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 大型抑郁症 (MDD) 与有自杀企图的患者的大脑结构变化有关.
- 自杀性MDD患者中与年龄相关的结构性大脑变化尚未得到充分理解.
研究的目的:
- 系统地审查和总结患有严重抑郁症和有史以来自杀企图的患者年龄特定的结构性大脑变化.
- 为了确定常见的和与年龄相关的脑电路变化,与整个生命周期的自杀风险相关.
主要方法:
- 根据PRISMA指南进行了系统审查.
- 搜索了Embase,PubMed和Web of Science的基于voxel和基于表面的形态学研究,直到2023年1月.
- 包括比较自杀性MDD患者与MDD或健康对照者的研究,按年龄分组 (青少年,中年,老年).
主要成果:
- 包括17项研究:3项是关于晚年抑郁症 (LLD),11项是关于中年抑郁症 (MAD) 和3项是关于青少年抑郁症 (AOD).
- 所有年龄组都表现出前额叶的改变;自杀性MAD患者与自杀性LLD患者相比,背侧前额叶皮层灰质减少.
- 在自杀性MAD和LLD患者中,皮层厚度和左角环体积下降,但在自杀性AOD患者中增加.
结论:
- 本综述强调了不同年龄组自杀性MDD患者常见的和年龄特定的结构性大脑变化.
- 这些发现有助于理解整个生命周期中自杀的神经电路.
- 这些结果可能有助于根据年龄预测MDD患者的自杀风险.
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