长期的COVID与严重的认知减速有关:一个多中心的横截面研究
Sijia Zhao1, Eva Maria Martin2, Philipp A Reuken3
1Department of Experimental Psychology, University of Oxford, Oxford, OX2 6GG, UK.
EClinicalMedicine
|February 6, 2024
概括
认知减速是COVID-19后疾病 (PCC) 的关键标志物. 患有PCC的患者在简单反应时间 (SRT) 和持续注意力方面表现出显著的延迟,使他们与没有PCC的患者区别开来.
科学领域:
- 神经学 神经学
- 认知科学 认知科学
- 传染性疾病 传染性疾病
背景情况:
- 后COVID-19条件 (PCC) 可以导致慢性认知症状.
- 目前缺乏PCC的客观认知标记.
- 一般化的认知减速被假设为PCC潜在的常见缺陷.
研究的目的:
- 研究认知减速作为PCC的客观标志物.
- 为了比较PCC患者与对照组的认知表现.
主要方法:
- 来自英国和德国诊所的270名PCC患者完成了简单反应时间 (SRT) 和数值警测试 (NVT).
- 对照组包括以前患有COVID-19但没有PCC的个人 (无-PCC) 和未感染的个人 (无-COVID).
- 在2021年5月至2023年7月期间收集的数据.
主要成果:
- 与健康对照组相比,PCC患者表现出明显的认知减速,在SRT上显著减速.
- 超过50%的PCC患者的反应速度低于对照平均值2个标准偏差以上.
- 认知减缓并没有由并发症解释,并且与持续的注意力缺陷 (NVT) 相相关.
结论:
- 显著的认知减缓是PCC患者的一个强有力的发现,使其与没有PCC的个人区别开来.
- 认知减速可能是PCC体验的认知障碍的重要贡献者.
- SRT和NVT显示出作为评估PCC认知缺陷的客观措施的潜力.
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