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Updated: Jul 4, 2025

Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3
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Published on: August 17, 2011

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2'-脱氧-ADPR比ADPR更快地激活人类的TRPM2,从而在生理学Ca2+度下诱导更高的电流

Jelena Pick1, Simon Sander2, Stefanie Etzold1

  • 1The Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Frontiers in immunology
|February 6, 2024
PubMed
概括

由于更快的动力学和更高的敏感性,2-脱氧-ADP-ribose (2dADPR) 比ADP-ribose (ADPR) 更有效地激活TRPM2通道. 这表明2dADPR是先天免疫反应的主要生理激活剂.

关键词:
2′-脱氧-ADPR 的使用.在 ADPr.TRPM2TRPM2TRPM2TRPM2TRPM2TRPM2TRPM2TRPM2TRPM2TRPM2TRPM2TRPM2TRPM2TRPM2TRPM2对于的敏感性信号传递的.卡尔莫杜林是一种卡尔莫杜林.

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