相关实验视频
Updated: Jun 24, 2026

16:11
Implantation of the Syncardia Total Artificial Heart
Published on: July 18, 2014
35.3K
植入前免疫状态与左心室辅助装置植入后感染风险有关
Maja-Theresa Dieterlen1, Eva Katharina Messer1, Kristin Klaeske1
1University Clinic of Cardiac Surgery, Leipzig Heart Center, HELIOS Clinic, Leipzig, Germany.
Journal of inflammation research
|February 6, 2024
概括
在手术前接受左心室辅助装置 (LVAD) 的患者,淋巴细胞数量较低和特定免疫细胞百分比较低,患早期植入后感染的风险更高. 植入前免疫状态可以预测LVAD接受者的感染风险.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 感染是左心室辅助装置 (LVAD) 植入后的常见并发症.
- LVAD患者的手术前免疫状况及其与术后感染风险的相关性仍然不清楚.
研究的目的:
- 为了调查特定的LVAD前免疫状况是否使患者在植入后三个月内感染.
- 为了比较早期感染的LVAD患者和没有感染的LVAD患者之间的LVAD前免疫学参数.
主要方法:
- 54名LVAD患者根据植入后的前三个月被分为感染 (n=23) 和无感染 (n=31) 组.
- 在LVAD前的血液样本使用流式细胞计对免疫细胞群 (T细胞,B细胞,树突细胞) 进行了分析.
- 记录了中性粒细胞与淋巴细胞的比率 (NLR) 和其他临床数据.
主要成果:
- 患有感染的患者在LVAD前的淋巴细胞度明显降低 (p=0.02).
- 在感染组中观察到CD3+ T细胞,CD19+ B细胞和血细胞树突细胞 (pDC) 的百分比较低.
- 在患有感染 (40% vs 14%,p=0.05) 的患者中,观察到LVAD前中性粒细胞与淋巴细胞比率 (NLR) >7的更高患病率.
结论:
- 特定的LVAD前免疫变化,包括淋巴细胞减少和树突细胞种群变化,与早期术后感染的风险增加有关.
- 手术前的免疫分析可能有助于识别感染风险较高的LVAD患者,从而实现有针对性的预防策略.
相关概念视频
Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Endocarditis I: Introduction
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Endocarditis III: Medical Management
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Endocarditis IV: Nursing Management
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Cardiomyopathy V: Interprofessional Care
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

