细胞衰老在慢性病中的血管化过程中的功能性作用
Ya-Ping Fang1, Yu Zhao1, Jia-Yi Huang2
1Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China.
Frontiers in endocrinology
|February 6, 2024
概括
细胞衰老驱动慢性病中的血管化. 衰老细胞促进炎症和损害修复,加速心血管事件.
科学领域:
- 心血管生物学 心血管生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 细胞衰老 细胞衰老
背景情况:
- 血管化 (VC) 是慢性病 (CKD) 中心血管事件的主要危险因素.
- 加快的血管衰老和细胞衰老越来越被认为是CKD中VC的关键贡献者.
- 衰老的血管细胞释放促进化和炎症的因素.
研究的目的:
- 综合审查血管细胞衰老在VC发展和进展中的作用.
- 突出细胞衰老有助于CKD患者的VC的机制.
- 强调了解细胞衰老对于开发心血管疾病的抗衰老疗法的重要性.
主要方法:
- 对调查血管细胞衰老和CKD中的VC研究的文献综述.
- 分析涉及衰老的血管内皮细胞 (VEC) 和血管光滑肌细胞 (VSMC) 的机制.
- 检查与衰老相关的分泌表型 (SASP) 和其炎症作用.
主要成果:
- 衰老的VECs释放微,诱导VSMC衰老和骨质过渡,促进VC.
- 衰老的血管原生细胞有受损的分化和释放SASP,延续衰老.
- SASP创造了一个亲炎性微环境,招募免疫细胞并加剧VC.
结论:
- 血管细胞衰老是CKD中VC的关键驱动因素,有助于加速血管衰老.
- 准细胞衰老和SASP可能为缓解CKD中心血管疾病提供新的治疗策略.
- 了解衰老和VC之间的相互作用对于推进抗衰老干预至关重要.
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