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术后和局部对照结果连续的短疗程放射治疗和化疗用于直肠癌

I-Chia Liu¹, Susan Gearhart², Suqi Ke³

¹Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Surgery open science

|February 6, 2024

概括

总的新辅助疗法 (TNT) 使用短期放射治疗,然后进行化疗,改善局部晚期直肠癌 (LARC) 的结果. 这种方法显示了完全切除的高率和优秀的两年局部控制.

科学领域:

在瘤学瘤学.
外科胃肠道外科手术
辐射瘤学辐射瘤学

背景情况:

总的新辅助疗法 (TNT) 越来越多地用于局部晚期直肠癌 (LARC).
与标准的新辅助疗法相比,TNT旨在减少转移性疾病.
在TNT中进行辐射和化疗的最佳序列和时间需要进一步调查,特别是关于手术结果.

研究的目的:

评估手术样品质量,术后并发症和局部/盆腔控制.
评估在接受TNT的LARC患者中辐射和手术之间的间隔的影响.
分析短期放射治疗 (SCRT) 后的结局,其次是巩固化疗和手术.

主要方法:

83名接受SCRT,巩固化疗和手术的LARC患者的回顾性审查.
对手术样本结果的分析,包括完整/近乎完整的间直肠切除.
术后并发症的评估和两年的局部/盆腔控制率.

主要成果:

在90%的患者中,获得了完整/近乎完整的中肠直肠样本.
放射治疗完成和手术之间的时间间隔没有显著影响手术结果.
两年的局部控制高 (总体为93.4%),低风险为97.6%,高风险为90.4%.

结论:

前期的SCRT随后的整合化疗是LARC的有效新辅助策略.
经过SCRT后的延长间隔不会影响手术样本的质量.
这种TNT序列为LARC患者提供了有利的外科和瘤治疗结果.

关键词:

切除前膜术 (Proctectomy) 是一种切除前膜术.放射治疗疗法放射治疗疗法这是直肠癌.

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